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KMID : 0377519930180030323
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Chung-Ang Journal of Medicine
1993 Volume.18 No. 3 p.323 ~ p.332
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A Study on the CI-Current Attributed to the Genesis of Action Potental in Gastric Antral Smooth Muscle Cells
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방효원
이종찬/이무열/엄대용/이상돈
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Abstract
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Chloride current has been known as a part of background current, recently, its roles in the maintenance of action potential have much attention. The purposes of the present study are clarifying the chloride current component which might play an
important role in generation and maintenance of the action potential in the pyloric circular smooth muscle cells. We used the whole cell voltage clamp techniques to assess the current and voltage responses induced by caffeine superfusion.
@ES The results were as follows:
@EN 1. Caffeine superfusion induced the increase of inward currents in the hyperpolarized potential ranges, and the increase of outward currents in the depolarized ranges.
2. Sodium ion removal from the external medium and the addition of cadmium ion rarely affected these current response.
3. duration of the action potential was elongated by application of the caffeine and modified by the change of the intracellular chloride ion concentration.
4. The effect of caffeine superfusion on the action potential disappeared by the addition of the anion channel blocker.
The results suggest that caffeine superfusion may prolong the duration of repolarized phase of the action potential probably by the chloride current activation and the gastric antral smooth muscle.
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KEYWORD
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